Postdoctoral Researcher – Next-Generation CAR Immune Cell Therapies Against Malignant Brain Tumors (ERC-funded)

Generate CAR immune cell communities, comprising mixtures of engineered T cells, NK cells, monocytes, and additional cell types, using sophisticated in vitro and in vivo engineering platforms. Identify co-factors that boost CAR immune cell function using cutting-edge screening platforms. Investigate anti-tumor activity and immune-cancer-cell environmental crosstalk in vitro and in vivo using sophisticated disease models (organoids, slice cultures, patient-derived samples, mouse models) and modern technologies including flow cytometry, multiplexed imaging, spatial transcriptomics/proteomics and single-cell profiling. Analyze patient samples from an accompanying clinical trial evaluating CAR immune cell communities.

The University of Zurich, Switzerland's largest university, offers a range of attractive positions in various subject areas and professional fields. With around 10,000 employees and currently 12 professional apprenticeship streams the University offers an inspiring working environment on cutting-edge research and top-class education.

• Intellectual curiosity, creativity and a proactive approach to problem-solving

• Motivation to contribute to a project with direct patient impact

• PhD in immunology, computational immunology, cell/molecular/cancer biology, bioengineering, biomedical sciences, or a related field

• Experience with immune cell engineering, cellular immunotherapy, and/or advanced in vitro/in vivo disease models is highly desirable

• Familiarity with single-cell and/or spatial technologies is a plus

• Strong publication record demonstrating scientific productivity

• Excellent communication skills and the ability to thrive in an interdisciplinary team