RNA Biology Associate in oligonucleotide screening

Support screening oligonucleotide-based therapeutics and development of RNA technologies by setting up and executing various molecular biology assays.

Develop cell-based screening assays and perform cell culture maintenance

Implement lab automation for high throughput screening of oligonucleotides

Purification and handling of RNA samples

Perform digital PCR, quantitative PCR (qPCR) assays to support portfolio and platform projects

Prepare and process tissue samples from animal studies for subsequent molecular analyses.

Assist in setting up and executing advanced molecular biology assays, including transcriptome profiling (e.g., DRUG-Seq, BRB-Seq, RNA-Seq).

In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

Therapeutic Modalities (TMo) organization, accountable for translating disease biology into high-quality drug candidates across small molecules, large molecules, oligonucleotides, and genomic medicines. By integrating deep modality expertise with cross-disciplinary collaboration, TMo drives innovation within and across platforms to enable differentiated, sustainable therapeutic impact.

We are looking for an experienced Lab Associate with a focus on molecular biology and RNA biology tasks to join our Nucleic-acid-based medicines team.

• B.Sc in molecular biology or related field with a minimum of 10 years experience in drug discovery or M.Sc with a minimum of 5 years experience

• Experience with therapeutic oligonucleotides, including screening and in vitro characterization

• Hands-on wet-lab experience with molecular biology, RNA biology techniques (qPCR) & lab automation, ideally in an industrial setup

• Strong organizational skills and attention to detail

• Ability to work collaboratively in a team environment