PhD Position (Tumor Immunology and Neuro-Oncology)

Investigate mechanisms maintaining the immunosuppressive myeloid microenvironment of glioblastoma and identify strategies to therapeutically reverse them Develop and apply cellular and patient-derived models, including primary immune and tumor cell cultures, co-cultures, organoids and tumor explants Build and perform functional screening approaches to evaluate myeloid-directed immunotherapies, including live-cell imaging, phagocytosis and immune activation assays Characterize treatment responses using multiparameter flow cytometry, spatial profiling and single-cell sequencing, and integrate experimental and clinical data Advance promising therapeutic strategies toward translational validation, including antibody engineering, predictive biomarker development and in vivo testing

Es gibt viele Gründe, zu uns zu kommen: Am USB arbeiten heisst in erster Linie, Teil eines engagierten Teams aus über 7500 Mitarbeitenden aus rund 90 Nationen zu sein. Unser lebhafter Alltag ist geprägt von zukunftsweisender Forschung, Spitzenmedizin und Wissenstransfer auf höchstem Niveau. Dazu kommen eine moderne Unternehmenskultur, Inter-disziplinarität, inspirierende Innovationskraft und vielseitige Aus- und Weiterbildungsmöglichkeiten.

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• Master's degree or equivalent in immunology, cancer biology, biomedical or life sciences, molecular medicine, pharmaceutical sciences or a related field; medical graduates with a strong interest in laboratory research are also welcome

• Hands-on laboratory experience, ideally in cell culture and cellular or molecular immunology

• Strong interest in tumor immunology, myeloid biology and translational cancer research, with a motivation to connect mechanistic research to therapeutic applications

• Curiosity for new experimental methods and quantitative data analysis; experience with R or Python is advantageous but not required

• Initiative, reliability and the ability to work collaboratively in an interdisciplinary environment; willingness to work with mouse models and excellent English language skills are required