F. Hoffmann-La Roche AG

Senior/Principal Scientist - NMR Expert

📍 4070 Basel

Rolle und Verantwortlichkeiten

In this role you plan, run and report NMR experiments for structure elucidation and inter- and intra-molecular interaction studies. By applying cutting-edge analytics you support synthesis and formulation development enabling fast progress for projects, and identification of possible challenges. You develop and implement new NMR experiments and give input for future developments of our NMR group. You enhance scientific excellence by identifying relevant industry trends, and building and maintaining academic partnerships. You contribute deep scientific insights to shape the mid- and long-term strategy for NMR within the Roche portfolio. Working alongside the NMR group and the Leadership Team, you guide the translation of your strategic input into actionable team strategies. You foster trustful relationships and effective collaboration with internal discovery and technical development teams as well as with external partners.

Team / Beschreibung

In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicine. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. This role is situated within the preclinical Chemistry, Manufacturing, and Controls (pCMC) department, part of the Small Molecule Research organization in pRED Therapeutic Modalities (TMo). We pave the path for drug candidates from early research to development in a diverse, ambitious, and innovative environment. Collaborating actively with our discovery and development partners, we leverage cutting-edge technologies and scientific excellence to transform molecules into future medicines. As CMC experts, we bring a rich diversity of technical expertise in chemistry, formulation design, material science, and analytical chemistry, pioneering advancements in small molecules, peptides, and nucleic acid-based medicines.

Qualifikationen und Fähigkeiten

  • Masters with a minimum of 5 years or PhD in analytical chemistry or related fields with a minimum of 3 years of professional experience in the industry.

  • Comprehensive knowledge of NMR analytics and its applications paired with a deep understanding of the technical and theoretical basis beyond the standard experiments for liquid and solid state NMR. Experience with other methods for biophysical characterization is a plus.

  • Hands on expertise in structure elucidation and interaction studies by NMR for synthetic oligonucleotides and/or peptides. Demonstrated expertise on higher order structure studies and aggregation studies.

  • You possess an open-minded and highly proactive, "just-do-it" approach. You enjoy problem-solving and developing new ways of working. You comfortably navigate working in a multidisciplinary matrix team.