Cardio-Renal Discovery Area Leader - Expert Scientist

Your key responsibilities will include: Novel Target Identification: Drive scientific strategy to validate disease-modifying targets across CV and renal segments. Mechanistic Subspecialties: Champion programs targeting advanced mechanisms like myocardial energetics and podocyte injury. Modality-Agnostic Innovation: Lead teams across small molecules, RNA-based therapeutics, and advanced biologics. Phenotypic & Human-Centric Screening: Oversee 3D cardiac organoids and kidney-on-a-chip models. Preclinical-to-Clinical Translation: Accountability for scientific integrity of preclinical pharmacology and design architecture for transitioning leads into IND/CTA-enabling packages. Scouting & Due Diligence: Serve as technical authority for evaluating external assets and biotech platforms. Scientific Eminence: Cultivate collaborative relationships with academic research networks and consortia.

In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. pRED Cardiovascular & Metabolism, Immunology (CMI), located in Basel, Switzerland, focuses on the discovery and early development of innovative treatments for specific diseases that affect the lives of millions. In the cardiovascular and metabolism area, we are developing cutting-edge therapies to treat metabolic diseases.

• 10+ years of progressive biopharmaceutical industry or premier academic translation experience, with a documented history of driving CV/renal assets from early concept to successful IND/CTA filing and FIH readiness.

• Education Level: PhD, MD, or MD/PhD in Cardiovascular Physiology, Renal Physiology, Pharmacology, Molecular Biology, or a highly relevant life sciences discipline.

• Advanced authority on the pathophysiology of cardiorenal networks, including CKD/Nephropathy, Myocardial Remodeling & Fibrosis, the Cardiorenal Axis, Genetic & Rare Diseases, and Atherosclerosis & Lipid Metabolism.

• Fluency in English (written and spoken) is required.