PhD Student Infection Biology and Biomedical Materials

Establish and optimise advanced 3D in vitro infection models (e.g. staphylococcal abscess communities) Investigate early events in infection establishment, including bacterial aggregation, fibrin encapsulation, and antibiotic tolerance Characterise neutrophil–bacteria interactions, including phagocytosis, ROS production, and bacterial killing Identify and evaluate immunomodulatory compounds that enhance neutrophil function Perform cell culture and co-culture experiments using primary human neutrophils and bacterial pathogens Apply advanced techniques including confocal microscopy, flow cytometry, and molecular assays Analyse and interpret complex experimental datasets Contribute to interdisciplinary collaboration with biomaterials researchers within the PREPARE project

The AO is a medically guided, not-for-profit organization, a global network of surgeons, and the world's leading education, innovation, and research organization specializing in the surgical treatment of trauma and musculoskeletal disorders. We are home to people from all over the world, from different backgrounds, with diverse talents and specialist areas. What binds us together is our passion for excellence, our dedication to our mission of improving patient care, and our understanding that we are stronger together: we are one AO. The AO Research Institute Davos (ARI) contributes high quality applied preclinical research and development within trauma and disorders of the musculoskeletal system and translation of this knowledge, as well as investigates and improves the performance of surgical procedures, devices, and substances to achieve more effective patient care worldwide. It fosters a close relationship with the AO’s medical community, academic societies, and universities and provides a research environment and support for AO clinicians.

• Master’s degree in microbiology, infection biology, immunology, or a related life science discipline

• Practical experience in microbiology and/or host–pathogen interaction studies

• Experience with cell culture and immunological assays (e.g. flow cytometry, microscopy)

• Strong interest in infection biology, innate immunity, and translational research

• Ability to design, plan, and execute experimental studies independently

• Excellent communication skills in English

• Motivation to work in a highly interdisciplinary and collaborative environment